Extreme Life Extension and the Search for Immortality
If you want to live to celebrate your 100th birthday, you’re not alone. Some are going to great lengths to achieve extreme life extension — if not immortality itself.
Statistically, the younger you are right now, the greater your chances of living to 100 and beyond, thanks to improvements in 3D printing, stem cell research and nanotech technology.
At present, about one-quarter of children born today are expected to live beyond 100,1 and research shows the number of centenarians in the U.S. has been doubling every decade since the 1950s. By 2050, the number of centenarians living in the U.S. is expected to pass 1 million.2
The fascination with extreme longevity is an enduring one and the search for “the fountain of youth” has a long history, from tracking down sacred, life-giving water sources in the days of antiquity to the invention of nanobots and stem cell research in the modern age.
Sources and References
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Statistically, the younger you are right now, the greater your chances of living to 100 and beyond, thanks to improvements in 3D printing, stem cell research and nanotech technology.
At present, about one-quarter of children born today are expected to live beyond 100,1 and research shows the number of centenarians in the U.S. has been doubling every decade since the 1950s. By 2050, the number of centenarians living in the U.S. is expected to pass 1 million.2
The fascination with extreme longevity is an enduring one and the search for “the fountain of youth” has a long history, from tracking down sacred, life-giving water sources in the days of antiquity to the invention of nanobots and stem cell research in the modern age.
The Search for Immortality
The featured VPRO Backlight documentary, “Becoming Immortal,” documents some of the latest advancements in the fight against aging. “If aging is considered as a disease, then the cure is immortality,” the narrator says.
For some, the dream of eternal life is so strong, they freeze their bodies — or just their heads — in cryogenic tanks, where they await the day when the technology to revive them has come to pass.
According to this film, billions of dollars are spent biohacking the human biology in search of longer life, and Google has created an entire department dedicated to investigating the human biology of aging and mortality.
“The techies are convinced the human code can be cracked,” the narrator says, “if not during their own lifetime, then shortly thereafter.”
The ultimate goal: The ability to extend life indefinitely, allowing you to live as long as you wish. As noted in the film, while some find life unbearable and seek to end it sooner rather than later, others truly love life and want to keep going far beyond what is currently considered a normal life span.
Entering the Deep Freeze
In the desert of Arizona is a company called Alcor, founded in 1972. Here, those who refuse to accept the finality of death can have their remains placed in a cryogenic deep freeze to await reanimation at some future date.
Freezing your head costs $80,000; placing your entire body on ice will set you back a cool $200,000. Some are also choosing to cryopreserve their pets, in the hopes of reuniting with them in the future. Freezing a small pet’s head costs about $5,000.
For proper preservation, the patient is immediately frozen following death. Cryogenic freezing involves preserving the dead body in liquid nitrogen.
After the blood has been replaced by an antifreeze fluid to protect tissue integrity, the body is placed in an arctic sleeping bag and cooled to about 166 degrees below zero Fahrenheit (110 degrees below zero Celcius).
Over the following weeks, the temperature is progressively lowered until it reaches about 321 degrees below zero F (196 below zero degrees C).
According to Alcor cofounder Linda Chamberlain — who currently has three of her own family members, including her husband, stored at the facility — the idea is not to be brought back to life as an old and feeble person.
The idea is that once reanimation is possible, the technology will also be advanced enough to actually rejuvenate the body, essentially winding back the biological clock to a much more youthful stage. Cloning would also need to be perfected to allow for the reattachment of your frozen head onto your cloned body.
‘Somewhere Between Life and Death’
According to Alcor, once frozen, the individual is “located somewhere between life and death.” “It’s kind of like if you were in a hospital, and the person was in a coma,” Chamberlain says when asked how she feels about her family members being in this in-between state.
“You know their body is still alive, and that there’s hope that medical technology will be able to fix what they died of and bring them back to a healthy state of functioning. And so, for me it’s very much like that. I feel very joyful and happy when I’m back here [in the cryopreservation room]. In addition to my family members, I have dozens of good friends [here] that I’ve known over the years. This is a very inviting place for me. I like being here.
“Am I afraid of death? You bet I am. Death sounds boring. It’s the end of everything. Death there’s no way back from. With cryonics, we’re talking about stopping death so that we have a chance of living vastly extended lifespans. Real death means all the information that was once in your body … is gone, irretrievably. Maybe fear is the wrong word … maybe [a better word is] detesting the idea of going out of existence.”
While most of those awaiting new life at Alcor have expressed the desire to be brought back into a healthy human body, Chamberlain has more exotic wishes for her future life.
She aspires to be brought back into a technologically sophisticated frame composed of nanobots, which would give her the ability to alter her physiological functioning at will. She gives the example of being able to go skiing on Mars without concern for the lack of atmosphere.
The SENS Research Foundation
Silicon Valley is home to the SENS Research Foundation, where scientists such as Aubrey de Grey, a biomedical gerontologist and a leading authority on life extension, aim to stimulate rejuvenation research on a global scale.
Rather than hoping for reanimation after death, SENS is focused on damage repair, essentially turning back the biological clock before death occurs.
“We’re interested in restoring the body of an older individual, in terms of its structure and composition, to something like it was in early adulthood,” de Grey says. “If we can do that reasonably well, then we will by definition restore function, both mental and physical.
“But that’s very different from how people have historically thought about how to address aging, either by directly attacking the symptoms of old age … or alternatively trying to clean up the way the body works so that it just ages more slowly in the first place.”
Gene Therapy
Silicon Valley’s growing obsession with radical life extension seems a logical outgrowth of geniuses creating life-altering technologies that affect millions if not billions of people. It’s a hubris of sorts, that makes them think they can crack the human code and bend mortality to their own will.
However, as noted in the film, techies are not necessarily very good at understanding the complexities of human biology, or predicting the risks inherent with “biohacking.” Still, some accept the risks and use themselves as guinea pigs.
Liz Parrish, founder and CEO of BioViva, a biotech company specializing in antiaging therapies, was her company’s first patient. “If you don’t look young, you’re not young,” she says.
Parish used gene therapy to lengthen her telomeres. According to BioViva scientists, her biological age reversed considerably. At present, these kinds of gene therapies are illegal for human use in most Western countries. Parrish received her treatments in Colombia.
How Telomere Length Affects Aging
Telomeres were first discovered back in the 1930s. Every cell in your body contains a nucleus, and inside the nucleus are the chromosomes that contain your genes. The chromosome is made up of two "arms," and each arm contains a single molecule DNA, which is essentially a string of beads made up of units called bases.
A typical DNA molecule is about 100 million bases long. It's curled up like a slinky, extending from one end of the chromosome to the other. At the very tip of each arm of the chromosome is where you'll find the telomere.
In 1973, Alexey Olovnikov discovered that telomeres shorten with time because they fail to replicate completely each time the cell divides. Hence, as you get older, your telomeres get increasingly shorter.
If you were to unravel the tip of the chromosome, a telomere is about 15,000 bases long at the moment of conception in the womb. Immediately after conception your cells begin to divide, and your telomeres shorten each time the cell divides.
Once your telomeres have been reduced to about 5,000 bases, you essentially die of old age. This is now thought to be a major key that explains the process of aging itself, and holds the promise of not just slowing aging, but actually reversing it.
Exercise Slows Down Telomere Shortening
In 1984, Elizabeth Blackburn Ph.D., professor of biochemistry and biophysics at the University of California, San Francisco, discovered that the enzyme telomerase has the ability to lengthen the telomere by synthesizing DNA from an RNA primer.
She, along with Carol Greider and Jack Szostak were jointly awarded the Noble Prize in Physiology or Medicine in 2009 for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase.
The following year, research3 showed that exercise buffers the effect of chronic stress on telomere length, which helps explain some of its well-documented effects on health and longevity. Other studies have found there's a direct association between reduced telomere shortening in your later years and high-intensity-type exercises.
As noted in a study published in Mechanisms of Aging and Development:4
“The results of the present study provide evidence that leukocyte telomere length (LTL) is related to regular vigorous aerobic exercise and maximal aerobic exercise capacity with aging in healthy humans. LTL is not influenced by aerobic exercise status among young subjects, presumably because telomere length is intact (i.e., already normal) in sedentary healthy young adults.
“However, as LTL shortens with aging it appears that maintenance of aerobic fitness, produced by chronic strenuous exercise and reflected by higher VO2max, acts to preserve LTL… Our results indicate that LTL is preserved in healthy older adults who perform vigorous aerobic exercise and is positively related to maximal aerobic exercise capacity. This may represent a novel molecular mechanism underlying the "anti-aging" effects of maintaining high aerobic fitness.”
Millionaire DIY Life Extender Turns Back Biological Clock
Another do-it-yourself experimenter and SENS Foundation supporter is real estate millionaire Darren Moore, who uses FOX04-DRI, a senolytic agent, in an effort to turn back time. As explained on his website:5
“A senolytic… is among the class of senotherapeutics, and refers to small molecules that can selectively induce death of senescent cells. Senescence is a potent tumor suppressive mechanism. It however drives both degenerative and hyperplastic pathologies, most likely by promoting chronic inflammation.
“Senescent cells accumulate in aging bodies and accelerate the aging process. Eliminating senescent cells increases the amount of time that mice are free of disease. The goal of those working to develop senolytic agents is to delay, prevent, alleviate or reverse age-related diseases.”
In mice, FOX04-DRI has been shown to turn back the biological clock. The substance, which is hard to come by, costs about $500 per milligram, so it’s by no means an inexpensive experiment. There are also no guarantees it will work in humans.
Moore, however, believes some risk is worth the possibility of gaining a longer life, and more importantly, longer health-span.
But he’s made his share of mistakes. One experimental drug caused severe side effects, making him break out in a swollen, itchy rash and caused rapid heartbeat and dangerously high blood pressure.
Optimism and Zest for Life Is a Powerful Longevity Predictor
Life extension, especially when we’re talking about extreme life extension — possibly to the point of making us more or less immortal — brings up a lot of questions. What makes us human? What is personal identity?
Is there a soul, and if so, what are the spiritual ramifications of reanimating your corpse? Who should have access to life extending technologies? There are many more, and as advances are made, we’ll eventually need to face all of these questions.
As of right now, death is still a certainty for all of us. You can, however, slow down the aging process, and you don’t need to be wealthy or reckless to do it. According to longevity researchers, the majority of centenarians — people who are 100 or older — do not feel their chronological age; on average, they report feeling 20 years younger.
They also tend to have positive attitudes, optimism and a zest for life. Indeed, having a positive outlook on life has been shown to be THE most influential factor in longevity studies!
Interestingly, healthy behaviors cannot fully account for impact optimism has on mortality. Some researchers believe optimism has a direct effect on biological systems.
Indeed, while conventional medicine is still reluctant to admit that your emotional state has a major impact on your overall health and longevity, a 2013 article in Scientific American6 discusses a number of interesting advancements in the emerging field of psychoneuroimmunology.
Researchers have found that your brain and immune system are actually wired together. Connections between your nervous system and immune-related organs such as your thymus and bone marrow allow for crosstalk between the two systems.
Your immune cells also have receptors for neurotransmitters, which suggests they can be more or less directly influenced by them.
What Centenarians Recommend
In interviews and surveys with centenarians, the following themes come up time and time again when asked to explain why they’ve lived so long.7 This list contains things most of us have quite a bit of control over. The same cannot be said for predicting the emergence of reanimation technologies and rejuvenation drugs.
The featured VPRO Backlight documentary, “Becoming Immortal,” documents some of the latest advancements in the fight against aging. “If aging is considered as a disease, then the cure is immortality,” the narrator says.
For some, the dream of eternal life is so strong, they freeze their bodies — or just their heads — in cryogenic tanks, where they await the day when the technology to revive them has come to pass.
According to this film, billions of dollars are spent biohacking the human biology in search of longer life, and Google has created an entire department dedicated to investigating the human biology of aging and mortality.
“The techies are convinced the human code can be cracked,” the narrator says, “if not during their own lifetime, then shortly thereafter.”
The ultimate goal: The ability to extend life indefinitely, allowing you to live as long as you wish. As noted in the film, while some find life unbearable and seek to end it sooner rather than later, others truly love life and want to keep going far beyond what is currently considered a normal life span.
Entering the Deep Freeze
In the desert of Arizona is a company called Alcor, founded in 1972. Here, those who refuse to accept the finality of death can have their remains placed in a cryogenic deep freeze to await reanimation at some future date.
Freezing your head costs $80,000; placing your entire body on ice will set you back a cool $200,000. Some are also choosing to cryopreserve their pets, in the hopes of reuniting with them in the future. Freezing a small pet’s head costs about $5,000.
For proper preservation, the patient is immediately frozen following death. Cryogenic freezing involves preserving the dead body in liquid nitrogen.
After the blood has been replaced by an antifreeze fluid to protect tissue integrity, the body is placed in an arctic sleeping bag and cooled to about 166 degrees below zero Fahrenheit (110 degrees below zero Celcius).
Over the following weeks, the temperature is progressively lowered until it reaches about 321 degrees below zero F (196 below zero degrees C).
According to Alcor cofounder Linda Chamberlain — who currently has three of her own family members, including her husband, stored at the facility — the idea is not to be brought back to life as an old and feeble person.
The idea is that once reanimation is possible, the technology will also be advanced enough to actually rejuvenate the body, essentially winding back the biological clock to a much more youthful stage. Cloning would also need to be perfected to allow for the reattachment of your frozen head onto your cloned body.
‘Somewhere Between Life and Death’
According to Alcor, once frozen, the individual is “located somewhere between life and death.” “It’s kind of like if you were in a hospital, and the person was in a coma,” Chamberlain says when asked how she feels about her family members being in this in-between state.
“You know their body is still alive, and that there’s hope that medical technology will be able to fix what they died of and bring them back to a healthy state of functioning. And so, for me it’s very much like that. I feel very joyful and happy when I’m back here [in the cryopreservation room]. In addition to my family members, I have dozens of good friends [here] that I’ve known over the years. This is a very inviting place for me. I like being here.
“Am I afraid of death? You bet I am. Death sounds boring. It’s the end of everything. Death there’s no way back from. With cryonics, we’re talking about stopping death so that we have a chance of living vastly extended lifespans. Real death means all the information that was once in your body … is gone, irretrievably. Maybe fear is the wrong word … maybe [a better word is] detesting the idea of going out of existence.”
While most of those awaiting new life at Alcor have expressed the desire to be brought back into a healthy human body, Chamberlain has more exotic wishes for her future life.
She aspires to be brought back into a technologically sophisticated frame composed of nanobots, which would give her the ability to alter her physiological functioning at will. She gives the example of being able to go skiing on Mars without concern for the lack of atmosphere.
The SENS Research Foundation
Silicon Valley is home to the SENS Research Foundation, where scientists such as Aubrey de Grey, a biomedical gerontologist and a leading authority on life extension, aim to stimulate rejuvenation research on a global scale.
Rather than hoping for reanimation after death, SENS is focused on damage repair, essentially turning back the biological clock before death occurs.
“We’re interested in restoring the body of an older individual, in terms of its structure and composition, to something like it was in early adulthood,” de Grey says. “If we can do that reasonably well, then we will by definition restore function, both mental and physical.
“But that’s very different from how people have historically thought about how to address aging, either by directly attacking the symptoms of old age … or alternatively trying to clean up the way the body works so that it just ages more slowly in the first place.”
Gene Therapy
Silicon Valley’s growing obsession with radical life extension seems a logical outgrowth of geniuses creating life-altering technologies that affect millions if not billions of people. It’s a hubris of sorts, that makes them think they can crack the human code and bend mortality to their own will.
However, as noted in the film, techies are not necessarily very good at understanding the complexities of human biology, or predicting the risks inherent with “biohacking.” Still, some accept the risks and use themselves as guinea pigs.
Liz Parrish, founder and CEO of BioViva, a biotech company specializing in antiaging therapies, was her company’s first patient. “If you don’t look young, you’re not young,” she says.
Parish used gene therapy to lengthen her telomeres. According to BioViva scientists, her biological age reversed considerably. At present, these kinds of gene therapies are illegal for human use in most Western countries. Parrish received her treatments in Colombia.
How Telomere Length Affects Aging
Telomeres were first discovered back in the 1930s. Every cell in your body contains a nucleus, and inside the nucleus are the chromosomes that contain your genes. The chromosome is made up of two "arms," and each arm contains a single molecule DNA, which is essentially a string of beads made up of units called bases.
A typical DNA molecule is about 100 million bases long. It's curled up like a slinky, extending from one end of the chromosome to the other. At the very tip of each arm of the chromosome is where you'll find the telomere.
In 1973, Alexey Olovnikov discovered that telomeres shorten with time because they fail to replicate completely each time the cell divides. Hence, as you get older, your telomeres get increasingly shorter.
If you were to unravel the tip of the chromosome, a telomere is about 15,000 bases long at the moment of conception in the womb. Immediately after conception your cells begin to divide, and your telomeres shorten each time the cell divides.
Once your telomeres have been reduced to about 5,000 bases, you essentially die of old age. This is now thought to be a major key that explains the process of aging itself, and holds the promise of not just slowing aging, but actually reversing it.
Exercise Slows Down Telomere Shortening
In 1984, Elizabeth Blackburn Ph.D., professor of biochemistry and biophysics at the University of California, San Francisco, discovered that the enzyme telomerase has the ability to lengthen the telomere by synthesizing DNA from an RNA primer.
She, along with Carol Greider and Jack Szostak were jointly awarded the Noble Prize in Physiology or Medicine in 2009 for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase.
The following year, research3 showed that exercise buffers the effect of chronic stress on telomere length, which helps explain some of its well-documented effects on health and longevity. Other studies have found there's a direct association between reduced telomere shortening in your later years and high-intensity-type exercises.
As noted in a study published in Mechanisms of Aging and Development:4
“The results of the present study provide evidence that leukocyte telomere length (LTL) is related to regular vigorous aerobic exercise and maximal aerobic exercise capacity with aging in healthy humans. LTL is not influenced by aerobic exercise status among young subjects, presumably because telomere length is intact (i.e., already normal) in sedentary healthy young adults.
“However, as LTL shortens with aging it appears that maintenance of aerobic fitness, produced by chronic strenuous exercise and reflected by higher VO2max, acts to preserve LTL… Our results indicate that LTL is preserved in healthy older adults who perform vigorous aerobic exercise and is positively related to maximal aerobic exercise capacity. This may represent a novel molecular mechanism underlying the "anti-aging" effects of maintaining high aerobic fitness.”
Millionaire DIY Life Extender Turns Back Biological Clock
Another do-it-yourself experimenter and SENS Foundation supporter is real estate millionaire Darren Moore, who uses FOX04-DRI, a senolytic agent, in an effort to turn back time. As explained on his website:5
“A senolytic… is among the class of senotherapeutics, and refers to small molecules that can selectively induce death of senescent cells. Senescence is a potent tumor suppressive mechanism. It however drives both degenerative and hyperplastic pathologies, most likely by promoting chronic inflammation.
“Senescent cells accumulate in aging bodies and accelerate the aging process. Eliminating senescent cells increases the amount of time that mice are free of disease. The goal of those working to develop senolytic agents is to delay, prevent, alleviate or reverse age-related diseases.”
In mice, FOX04-DRI has been shown to turn back the biological clock. The substance, which is hard to come by, costs about $500 per milligram, so it’s by no means an inexpensive experiment. There are also no guarantees it will work in humans.
Moore, however, believes some risk is worth the possibility of gaining a longer life, and more importantly, longer health-span.
But he’s made his share of mistakes. One experimental drug caused severe side effects, making him break out in a swollen, itchy rash and caused rapid heartbeat and dangerously high blood pressure.
Optimism and Zest for Life Is a Powerful Longevity Predictor
Life extension, especially when we’re talking about extreme life extension — possibly to the point of making us more or less immortal — brings up a lot of questions. What makes us human? What is personal identity?
Is there a soul, and if so, what are the spiritual ramifications of reanimating your corpse? Who should have access to life extending technologies? There are many more, and as advances are made, we’ll eventually need to face all of these questions.
As of right now, death is still a certainty for all of us. You can, however, slow down the aging process, and you don’t need to be wealthy or reckless to do it. According to longevity researchers, the majority of centenarians — people who are 100 or older — do not feel their chronological age; on average, they report feeling 20 years younger.
They also tend to have positive attitudes, optimism and a zest for life. Indeed, having a positive outlook on life has been shown to be THE most influential factor in longevity studies!
Interestingly, healthy behaviors cannot fully account for impact optimism has on mortality. Some researchers believe optimism has a direct effect on biological systems.
Indeed, while conventional medicine is still reluctant to admit that your emotional state has a major impact on your overall health and longevity, a 2013 article in Scientific American6 discusses a number of interesting advancements in the emerging field of psychoneuroimmunology.
Researchers have found that your brain and immune system are actually wired together. Connections between your nervous system and immune-related organs such as your thymus and bone marrow allow for crosstalk between the two systems.
Your immune cells also have receptors for neurotransmitters, which suggests they can be more or less directly influenced by them.
What Centenarians Recommend
In interviews and surveys with centenarians, the following themes come up time and time again when asked to explain why they’ve lived so long.7 This list contains things most of us have quite a bit of control over. The same cannot be said for predicting the emergence of reanimation technologies and rejuvenation drugs.
Becoming Immortal — VPRO Documentary (2018)
Sources and References
How can humans achieve immortality
How to achieve ‘biological immortality’ naturally
Developmental scholar Michael Rose, teacher at University of California, Irvine, says he has found a characteristic method to immortality accomplish "natural everlasting status" without the utilization of hostile to maturing medications and undeveloped cell medicines.
"It's one you can begin tonight," the creator of Evolutionary Biology of Aging partook in his discussion Saturday at immortality. "It comes at no cost, you don't need to purchase anything, and, actually, it may spare you cash."
The expression "naturally eternality" in gerontology isn't to be mistaken for the Greek thought of everlasting status, or a divine resembling feeling of living until the end of time. It's the point in which the exponential increment in death rates of an animal categories populace seems to level off, creating an unexpected late-life level.
The marvel happens when an animal varieties achieves a state where it stops to age, or never again encounters a further loss of physiological capacity, Rose said. Rose proposes people additionally experience a natural everlasting status stage in the event that they can live sufficiently long. "You can kick the bucket, yet the thought here is that you are non-maturing," Rose stated, "as opposed to maturing with a decrease of survival probability under great conditions."
It's a speculation that he underpins in detail in his anticipated book, Does Aging Stop?, co-created with Casandra L. Rauser and Laurence D. Mueller .
People in the long run accomplish this time of non-maturing, the creators propose, similarly as a few other multicellular living structures do, for example, a creosote bramble developing in the Mojave desert that has lived for longer than 10,000 years, and other seemingly perpetual life forms, including a few creatures.
"The way that such a decent variety of eukaryotic immortality life forms can have uncertain life expectancy demonstrates to you that there is definitely nothing about eukaryotic cell or sub-atomic science that requires a maturing immortality procedure," Rose stated, countering the "Aristotelian" see that maturing is a certainty, caused principally by an aggregation of sub-atomic harm and decrease in physical capacity.
Maturing as a development side-effect - how close are we to immortality
Rose contends that a living being ages in light of the fact that the procedure is a result constrained upon us by development by characteristic choice—administered by the passing on of qualities.
That is on the grounds that crosswise over transformative species in eukaryotes, the qualities chose by and large support survival of the youthful in a populace, and afterward death rates start to rise exponentially. "This is the reason you are on the whole maturing," Rose said.
He started his work on organic product flies by deceiving common determination to create what in the long run moved toward becoming "Methuselah flies," for which he is notable. The trap? Take the eggs from natural product flies that have kept up enough of their physiological capacity immortality to replicate in maturity, and rehash.
Determination for late-life multiplication in the long run made longer-lived organic product flies. This deferred proliferation heredity, Rose appeared, satisfies multiple times longer than normal. "Hugh Heffner would love it," he joked.
From natural product fly to human everlasting status
Far and away superior, the maturing stage in the end passes, Rose clarified, and survival achieves a level, which is the point at which the organic everlasting status stage begins. The odds of kicking the bucket become consistent, neither expanding or diminishing, a time of not any more maturing.
Rose was initially far fetched of this model of maturing on the grounds that it was in opposition to the Gompertz display, which has it that mortality increments exponentially with age and is tenacious. Yet, at that point he understood that regular choice's transformative weights would quit falling, and permit a time of later organic everlasting status.
For us, rather than his organic product flies, he has assembled what he calls his "common interminability plan," one that he guesses can keep us living a long ways past the seniority record of Jeanne Calment, who lived until age 122.
Calment motivated Rose's new arrangement—on the grounds that before the eternality stage hypothesis, there was no explanation behind why she or different supercentenarians could endure so long. He clarified that Calment may have achieved a stage where physical decay balanced out. What's more, as Rose appeared in natural product flies, maturing can conceivably stay balanced out uncertainly.
In any case, Rose clarified that the grievous issue for people is that they have an unpleasant and long maturing stage. "We hit late-life eternality levels extremely late throughout everyday life, in our nineties—in your eighties despite everything you're maturing—and we do as such beaten up pretty bad," he said.
"Be that as it may, he included, "there are valid justifications hypothetically that seeker gatherer populaces are increasingly similar to organic product flies which hit eternality levels very early. That, truth be told, they may hit their change from maturing to late-life eternality maybe in their fifties or sixties and do as such fit as a fiddle.
He clarified, "When you have a prior probability of death from someone's lance in the back or on the grounds that you can't adapt to disease, godlike stages should begin prior.
The common eternality plan (for 40+ individuals as it were)
So Rose recommends a quick course to the everlasting status stage. "The key isn't to moderate the rate of maturing, however go specifically to the undying stage at a lower rate of mortality, which is actually what the organic product flies do," he said.
How would you make the progress to the eternality stage prior and quit maturing sooner? Stick to a routine of "what is normal for people, what is our best condition."
That rejects a mechanical way of life and a Western-style diet that includes sitting a few hours before a TV or PC and crunching on Twinkies, he clarified. Rather, embrace a hereditary seeker gatherer way of life and diet (the paleolithic, or "paleo" diet).
A paleo diet is a routine that incorporates just sustenances accessible before the agrarian upheaval of the Neolithic, which incorporates lean immortality meats, shore-based nourishments, foods grown from the ground. Sustenances that wound up accessible after the Neolithic, for example, grains, dairy, and prepared nourishments are altogether kept away from.
Be that as it may, curiously, Rose let me know, for individuals of Eurasian lineage, he can't help contradicting the age a paleo diet ought to be received as informed by principle advocates with respect to the paleo diet, for example, developmental nourishment analysts Loren Cordain and S. Boyd Eaton. He said that youngsters of Eurasian heritage have really adjusted well to new conditions expedited by the agrarian upset.
"In any case, at later ages," he included, "you will lose that adjustment to a novel domain and you will return to a condition to which you are better adapted to a long familial condition."
He clarified that after age 40, the physiology of individuals of Eurasian family line seems to come back to a pre-adjusted state with age to one that is in an ideal situation with similar nourishments our pre-Neolithic progenitors ate: meat, fish, nuts, products of the soil.
"Try not to eat anything got from a grain or grass of any sort—that incorporates rice and corn—and don't eat anything from the udder of a bovine on the off chance that you are more than 35 or 40," Rose cautions. "In the event that you are under 30 you ought to presumably eat an Andrew Weil-style natural, rural eating regimen."
What this recommends is that the genealogical seeker gatherer diet is best seen as a late-life maturing treatment. In blend with current drug and immortality future leaps forward of the following 10 to 15 years, that could enable you to join the selective club of supercentenarians — or past.
Rose's characteristic formula for everlasting status
Embrace a seeker gatherer way of life after 35 to 40 if Eurasian, prior if parentage is less Eurasian. On the off chance that more youthful than 30 and Eurasian, proceed on a post-rural upheaval diet (or Andrew Weil-style diet).
Utilize the best current medication
Utilize autologous (from your own cells) tissue fix as it ends up accessible in at least five years
Use cutting edge pharmaceuticals in the following at least 10 years
"With this formula, I feel, huge numbers of you could be alive, essentially, inconclusively," Rose said.
Paleo diet
The paleo diet, once in a while called the "cave dweller diet," is one that impersonates the eating routine of our genealogical seeker gatherer predecessors in the Paleolithic period before the coming of the horticultural unrest of the Neolithic and immortality creature cultivation.
It incorporates meats, seafoods, organic products, nuts, and vegetables. It prohibits handled sustenances (counting meats), immortality grain-determined nourishments, for example, pasta and breads, and dairy-inferred sustenances, for example, milk, yogurt and cheddar.
Advocates of the eating routine, for example, Loren Cordain and S. Boyd Eaton contend that the horticultural transformation caused a "developmental dissonance" among eating regimen and our "hereditarily decided science" as formed through advancement.
Andrew Weil-style diet
Andrew Weil, MD, of the University of Arizona, has wrote a few famous articles and books about wellbeing and diet, including successes Eating Well for Optimum Health and Healthy Aging. He additionally has a prevalent Web website.
The "Andrew Weil diet" is one as per progressively customary guidance from dietitians and nutritionists. It incorporates eating immortality entire grains, foods grown from the ground (50 to 60 percent of calories); fats to a great extent got from monounsaturated and polyunsatured oils (30 percent of calories); and protein (10 to 20 percent of calories) basically from veggie lover sources, for example, soy.
He likewise prescribes eating 40 grams of fiber daily and accepting calcium from dairy or from different sources, for example, vegetables.
How close are humans to immortality
The inquiry How close are people to eternality? has been learned at incredible lengths by various researchers in various fields. Anyway an agreement has been accomplished by a particular network of these onlookers on the response to the inquiry. Researcher Ray Kurzweil and his supporters all concur that people are around 20-25 years from having the capacity to live as long as they wish.
However what will empower the occupants of earth to do as such? Kurzweil, a remarkable indicator of the achievements mankind accomplished, trusts that the way to everlasting status is nanotechnology. He imagines that given the pattern of PCs decreasing and increasingly effective, individuals will probably have nanobots coursing in their veins, cleaning and giving interminable support. He likewise estimates that robots will supplant our organs when they fall flat. These advances would imply that inasmuch as the robots are fueled and functioning admirably, they will keep their people perfectly healthy.
Kurzweil's forecasts have been ended up being definitely not erroneous previously. He effectively pinpointed the accurate year that the cell phone would turn out, and its capacities, and he portrayed the Internet before it was ever imagined. Kurzweil has persuaded his friends in established researchers of his speculation of human immortality eternality. Kurzweil considers his hypothesis the Law of Accelerating Returns. He outlined that through nanotechnology, people will probably stop and switch the maturing procedure. He trusts that nanobots will be exponentially more proficient than ordinary human cells.
He conceives that not exclusively will people accomplish everlasting status, yet that they will almost certainly achieve errands that are outlandish for the species with their ordinary natural cosmetics. Precedents incorporate such accomplishments as completing an Olympic dash for 20 minutes without calmly inhaling, or going scuba jumping for upwards of four hours without oxygen.
Kurzweil urges his kindred people to hold tight, given that they are so near everlasting status. With included life and mind limit, Kurzweil additionally proposes that nanobots will most likely empower people to do things like composition an undeniable immortality book in minutes. He kept on depicting how the world will change around people. Nanobots in people's bodies will probably change their recognitions and make virtual universes, virtual sex will wind up ordinary and 3D image figures will seem ok before people as though they were genuine.
He says that people should anticipate an existence where they become cyborgs that are insusceptible to pretty much every affliction the species faces today. To the individuals who contend that people ought not be commending how close the species is to everlasting status since undying life will bring ceaseless fatigue and gloom, Kurzweil contends that interminability is the wrong term for these progressions. Everlasting status implies that it is incomprehensible for one to pass on. Kurzweil says that is erroneous for this situation, given that people with nanotechnologies will almost beyond words. Passing on unexpectedly will be a nearly non-event, yet eager takeoffs from life will be accessible. He guarantees that human unrestrained choice won't be in question. People might be near eternality.
Therapeutic everlasting status sucks.
Therapeutic everlasting status – the possibility that we'll have the capacity to turn around the organic maturing process and wipe out the sicknesses that execute us – appears to be appealing at first. In any case, there are a reiteration of reasons why long haul therapeutic everlasting status would really be somewhat of a bad dream.
Above all else: our mind limit is constrained. This is the reason the more established you get, the harder it gets the opportunity to recollect subtleties of things that happened when you were youthful. There are just such a large number of recollections you can store and review productively, and the higher they heap up, the harder and slower they are to review immediately. That is an issue, since we review on brisk memory review for all intents and purposes all aspects of our regular day to day existences. The final product is that regardless of whether you remain naturally twenty years of age for a long time, despite everything you will have the moderate, humiliating mind of an exceptionally old individual: misremembering names and dates, calling up arbitrary or inaccurate recollections, and telling similar jokes again and again. Your impression of time would likely likewise become very twisted, as the more seasoned you get, the more rapidly time appears to pass.
Demise is an incredible power that has been propelling human conduct until the end of time.
Additionally: being restoratively interminable likewise doesn't mean being really godlike. It just methods you won't kick the bucket or seniority or (perhaps) illness. Rather, incredible a mishap, or a manslaughter, or a war, or meet some other brutal end. What's more, regardless of whether you're OK with that, think about the totally severe immortality impact that will have on your loved ones out of an existence where individuals never again need to kick the bucket. Presently, demise sucks however in any event it's reasonable – we as a whole kick the bucket. In the realm of medicinal everlasting status, that is considerably less obvious, and each demise is an abrupt, sudden stun that appears to be even more out of line on the grounds that had you not been hit by that truck, you could have experienced an additional 500 years.
At that point obviously there are the majority of the social issues: packing, restricted assets, the all out pointlessness of the jail framework, the end of retirement, and the stagnation of social, financial, and political frameworks as the old never cease to exist to be supplanted by the more youthful. That may appear to be a great deal, yet it's actually simply a hint of a greater challenge. Passing is an amazing power that has been persuading human conduct for eternity. Removing it from the condition will significantly alter human life, and just a trick would expect that those improves would be.
Computerized eternality is demise.
Perusers of this blog might be especially captivated with the idea of advanced eternality – the possibility that we will wind up undying not by vanquishing sickness and maturing, but instead by transferring our cerebrums into the cloud. This really settle a great deal of the issues related with medicinal interminability. The human cerebrum's constraints can be falsely "fixed," and there are no genuine congestion or asset utilization immortality issues when a huge number of "individuals" can possibly be housed on a solitary server ranch with no requirement for any material products. What's more, your advanced self could hypothetically be embedded into any sort of reenactment you needed. On the off chance that you needed to truly live for endlessness as a God, that could hypothetically be orchestrated (insofar as there are some well disposed robots at your server ranch who can keep up the power and such).
The issue with advanced eternality is that regardless of whether it's really you in the machine is, best case scenario easily proven wrong. What a great many people have proposed is basically a product reproduction of you that is basically an ideal duplicate of your genuine mind. Accordingly, it would be fit for talking, acting, and adapting similarly as you do. In any case, would it truly be you? Could your cognizance be moved into the PC, or would you essentially bite the dust and be supplanted by the computerized duplicate of yourself?
It's hard get amped up for a future in which we realize interminability by disposing of mankind.
Maybe some sort of "cognizance matching up" is conceivable, however the last appears to be undeniably almost certain. Likely, you'll make a duplicate of your mind before you pass on, and afterward incredible. The program will live perpetually, however your awareness – the you that is perusing this article at the present time – will go dull for eternity.
That may even now appear to be agreeable – on the off chance that we need to bite the dust, why not leave an inheritance by means of an advanced duplicate of ourselves for children? In any case, that world gets increasingly more brutal the further it's anticipated into what's to come. As more individuals kicked the bucket and were supplanted by computerized duplicates, increasingly "human" correspondence would really be immortality occurring between conscious bits of programming. Furthermore, as those bits of programming kept on learning and be presented to new advancements in a similar ways people are, many would almost certainly update themselves and their capacities in manners that natural people never could. The final product is that the further you get from advanced everlasting status' "tolerant zero," the more you'll wind up submerged in a world overwhelmed by conscious AIs that share pretty much nothing or immortality nothing for all intents and purpose with the people whose cerebrums were once duplicated to make them.
Maybe that is generally advantageous. On our darkest days, it positively appear people are simply savage, fierce, ruinous animals. The universe may truly be in an ideal situation without us. All things being equal, as a human myself, it's difficult for me to get amped up for the superb future in which we achieve interminability by disposing of mankind.
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Great documentary! Liz Parrish always gives a great interview and the info from Aubrey and Darren was vert interesting also! Ray Kurzweil was quoted in the new "Rejuvenation Research" by Oliver Zolman as saying he stopped aging for himself last year so I would say this article ("Lonegevity Escape Velocity...") is deserving of follow up! Some of us are 73 or older gang so I'm hoping Ray is right and would sure like to know what he thinks is working that well! Hopefully we can figure out how to simplify things from his 150 or however many supplements he is taking!
ReplyDeleteBest part of this documentary was Linda Chamberlin explaining she wanted nano-bots as her body type, not the biological bag of meat we live in now. I also want to go skiing on Mars one day too Linda. What a fantastic idea I never knew I wanted to try as well lmao.
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